Stack Overview
The Ipamorelin and CJC-1295 combination is the most popular GH peptide stack. It combines a GHRP (Growth Hormone Releasing Peptide) with a GHRH (Growth Hormone Releasing Hormone) for synergistic growth hormone release.
This stack is used for:
- Fat loss (especially visceral/abdominal fat)
- Improved body composition
- Better sleep quality
- Enhanced recovery from training
- Anti-aging benefits
- Improved skin and hair
Why These Compounds Work Together
The Synergy Effect
GHRP and GHRH work on different parts of the GH release process:
- Ipamorelin (GHRP): Acts on the ghrelin receptor to trigger GH release - it's the "spark"
- CJC-1295 (GHRH): Amplifies the GH signal at the pituitary - it's the "fuel" [1]
When combined, 100mcg of CJC-1295 + 200mcg of Ipamorelin produces more GH than 200mcg of either alone. This is true synergy: 1+1=3. [3]
Why Ipamorelin Specifically?
Ipamorelin is the "cleanest" GHRP available: [2]
- Strong GH release comparable to GHRP-6 and GHRP-2
- Minimal cortisol increase (unlike GHRP-6/2) [2]
- No significant prolactin elevation
- No appetite stimulation (unlike GHRP-6)
Why CJC-1295 No DAC?
The "no DAC" version (also called Mod GRF 1-29) is preferred because:
- Short half-life allows natural pulsatile GH release [1]
- More physiological - mimics natural GH patterns
- Less risk of desensitization
- Can be precisely timed with Ipamorelin
Protocol
Standard Protocol
| Compound | Dose | Frequency | Timing |
|---|---|---|---|
| Ipamorelin | 200-300 mcg | 2-3x daily | Fasted |
| CJC-1295 (no DAC) | 100 mcg | 2-3x daily | With Ipamorelin |
Optimal Injection Times
Morning (Fasted)
Immediately upon waking. Wait 30-60 minutes before eating.
Post-Workout
Within 30 minutes of training. Don't consume carbs/fats beforehand.
Before Bed
30+ minutes after last meal. Amplifies the natural nighttime GH pulse.
Minimal Protocol (Budget/Convenience)
If you can only dose once daily:
| Ipamorelin + CJC-1295 | 200mcg + 100mcg | 1x before bed |
The pre-bed dose is most important as it enhances the natural sleep-time GH pulse.
Important: Fasted State
Reconstitution & Dosing
Ipamorelin (5mg vial):
Add 2ml BAC water = 2,500 mcg/ml
For 200 mcg: 8 units | For 300 mcg: 12 units
CJC-1295 (2mg vial):
Add 2ml BAC water = 1,000 mcg/ml
For 100 mcg: 10 units
Pro tip: You can draw both into the same syringe for convenience.
What to Expect
Timeline
- Week 1-2: Improved sleep quality, more vivid dreams
- Week 2-4: Better recovery, increased energy
- Week 4-8: Noticeable fat loss, especially around midsection
- Month 2-3: Improved skin quality, hair, body composition
- Month 3-6: Full anti-aging and body composition benefits
Side Effects
Generally well-tolerated. Possible effects include:
- Head rush: Brief sensation after injection, subsides in minutes
- Flushing: Temporary warmth, especially facial
- Water retention: Mild, usually in first few weeks
- Tingling: In fingers/hands (carpal tunnel-like), temporary
- Tiredness: Some feel sleepy, especially with bedtime dose
Duration & Cycling
This stack can be run long-term. Common approaches:
- Continuous: Many run 6+ months or indefinitely
- Cycling: 3-6 months on, 1-2 months off
- 5 days on, 2 off: Some cycle weekly
There's no established need to cycle, but some prefer breaks. GH peptides don't suppress natural production like exogenous HGH can.
Frequently Asked Questions
Do I need both or can I use one alone?
Either works alone, but the combination is synergistic. If choosing one, Ipamorelin is typically preferred for its clean profile and reliable GH release.
Can I use CJC-1295 with DAC instead?
Yes, but it's a different protocol. DAC version has an 8-day half-life and is dosed 1-2x weekly. It creates elevated baseline GH rather than pulsatile release.
How does this compare to HGH?
GH peptides stimulate your body to produce its own GH, maintaining natural pulsatile patterns. HGH provides exogenous GH. Peptides are generally considered safer long-term and don't suppress natural production.
Will I get results with once-daily dosing?
Yes, particularly the pre-bed dose. More frequent dosing amplifies results but once daily still provides benefits.
Related Stacks
- Healing Stack - Add for injury recovery
- Weight Loss Stack - For enhanced fat loss